Eric Dane, the actor known for his roles on Grey’s Anatomy and Euphoria, has died at 53, nearly one year after publicly revealing he had been diagnosed with amyotrophic lateral sclerosis, or ALS.

His death was confirmed by his family, according to NBC News. Dane first disclosed his diagnosis in April 2025 in a statement to People.

“I have been diagnosed with ALS,” Dane told the publication at the time. “I am grateful to have my loving family by my side as we navigate this next chapter.”

The announcement marked a turning point in a career that had already spanned decades of television and film.

The Work That Made Him a Household Name

Dane rose to prominence as Dr. Mark “McSteamy” Sloan on ABC’s Grey’s Anatomy. What began as a recurring role quickly became central to the series. His portrayal combined confidence, humor and emotional depth, helping define some of the show’s most memorable storylines.

Years later, Dane reintroduced himself to audiences in HBO’s Euphoria. As Cal Jacobs, he delivered a darker and more restrained performance, portraying a father confronting personal conflict and generational fracture. Critics noted the role as a demonstration of his range and willingness to take creative risks.

By the time he publicly shared his ALS diagnosis, Dane had built a body of work that connected with viewers across generations.

When He Spoke About ALS

After announcing his diagnosis, Dane remained visible. In interviews reported by NBC News and the Associated Press, he described first noticing weakness in his hand. At first, he attributed it to fatigue. When the weakness persisted and began affecting routine tasks, he sought medical evaluation. The diagnosis followed.

ALS, also known as Lou Gehrig’s disease, is a progressive neurological disorder that affects motor neurons, the nerve cells responsible for controlling voluntary muscle movement. As those neurons deteriorate, muscles weaken and gradually lose function.

According to the Centers for Disease Control and Prevention, approximately 30,000 Americans are living with ALS at any given time, with about 5,000 new cases diagnosed each year. The disease is considered rare, and there is currently no cure.

Early symptoms often include weakness in an arm or leg, muscle twitching, stiffness, difficulty gripping objects, or changes in speech. As the disease progresses, it can affect walking, swallowing and eventually breathing. Many individuals remain cognitively aware as physical abilities decline, which can add emotional complexity to the illness.

The National Institute of Neurological Disorders and Stroke reports that most people live three to five years after symptoms begin, although some survive longer.

Risk Factors and Ongoing Research

The cause of ALS remains unknown in most cases. The CDC reports that 90 to 95 percent of cases are sporadic, meaning they occur without a known family history. About 5 to 10 percent are familial and linked to inherited genetic mutations.

Risk factors include increasing age, particularly between 55 and 75, and male sex, though the disease affects both men and women. Researchers continue to study possible genetic and environmental contributors.

Dane’s public disclosure placed renewed attention on a condition that many people had heard of but knew little about.

A Broader Public Conversation

Dane’s death comes during a period when audiences have confronted several high profile illnesses within the entertainment industry. Earlier this year, this site reported on the death of actor James Van Der Beek from colon cancer, prompting conversation about cancer awareness and screening.

In Dane’s case, the focus has centered on ALS, a disease that remains incurable and deeply challenging for patients and families.

When actors speak openly about serious diagnoses, those illnesses become part of the broader public dialogue. Dane chose transparency, and in doing so, helped bring visibility to a rare neurological condition.

Remembering the Final Chapter

Eric Dane’s death at 53 marks the loss of a performer whose work shaped moments of television for nearly two decades.

His portrayal of Mark Sloan remains part of the cultural fabric of Grey’s Anatomy. His performance in Euphoria demonstrated his continued evolution as an actor. His final year, lived publicly after his ALS diagnosis, added a different dimension to how audiences understood him.

ALS altered the course of his last chapter. It did not erase the years that came before it.

His work remains widely watched. The awareness sparked by his diagnosis continues. And for many who followed his career, the connection formed through his performances endures beyond the headlines. And for his final act, Netflix releases a posthumous interview in Dane’s final message to his daughters and the world.